A 61 year old HIV positive woman from California has been identified by doctors as being an “elite controller” for the HIV virus – meaning her body is able to naturally keep the virus at bay, thus meaning it does her no harm.
Since being diagnosed 23 years ago, Loreen Willenberg hasn’t taken any drugs, has shown no symptoms of the virus, and has remained very healthy.
Scientists are hopeful that the rare genetic mechanism Loreen possesses (which only 1 percent of HIV patients are lucky to have) will help them to find a cure for the virus in the future.
Over the past decade, Loreen has participated in 13 studies, and she is hopeful one of them could lead to a cure.
‘If that happens before I go, then i will have, then I know that I have lived a good life,’ she said.
Her doctor, Dr. Richard Pollard,said: ‘Their body has such an effective way of reacting to the virus that it’s hard to even detect that they’re virus positive.’
Last year French scientists say they uncovered the genetic mechanism which appeared to have led two HIV-infected men to experience a ‘spontaneous cure’.
They say the discovery could lead to new treatments for the disease.
Both men were infected by the human immunodeficiency virus (HIV), one of them 30 years ago, but never developed AIDS symptoms.
The AIDS-causing virus remained in their immune cells but was inactivated because its genetic code had been altered, the scientists said.
The change appeared to be linked to increased activity of a common enzyme named APOBEC, they theorised.
The ‘apparent spontaneous cure’ throws up an intriguing avenue for drug engineers, the team said in a statement.
‘The work opens up therapeutic avenues for a cure, using or stimulating this enzyme, and avenues for identifying individuals among newly-infected patients who have a chance of a spontaneous cure.’
The work, published in the journal Clinical Microbiology and Infection, was carried out by scientists at France’s Institute of Health and Medical Research (Inserm).
HIV replicates by invading human CD4 immune cells, which it reprogrammes to become virus factories.
A rare group of people – fewer than one percent of those infected – are naturally able to rein in viral replication and keep the virus at clinically undetectable levels.
They are known as ‘elite controllers’, but the mechanism by which they keep the virus at bay remains a mystery.
A French group last year looked at two such individuals, a 57-year-old man diagnosed HIV-positive in 1985, and a 23-year-old diagnosed in 2011, and sequenced their virus genomes.
Though they remained infected, standard tests could not detect the virus in their blood.
The team found that in both cases, the virus was unable to replicate in immune cells due to mutations in its genetic code.
The researchers suggested spontaneous evolution between humans and the virus, a process called ‘endogenisation’ that is believed to have neutralised other viruses in humans in the past.
A similar process has been witnessed in a population of koalas that has integrated an AIDS-like virus into their genes, neutralised it, and were passing resistance on to their offspring.
‘We propose that HIV cure may occur through HIV endogenisation in humans,’ the team wrote.
‘These findings suggest that without therapeutic and prophylactic strategies, after several decades of HIV/host integrations and millions of deaths, it is likely that a few individuals might have endogenised and neutralised the virus and transmitted it to their progeny,’ they added.
‘We believe that the persistence of HIV DNA can lead to cure, and protection, from HIV.’
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