A British man who was given a polio vaccination as a kid has been found to have a highly virulent, mutant strain of the polio virus some 30 years later.
The discovery has prompted scientists to warn other patients who may unknowingly carry a similar strain and trigger new outbreaks of the disease.
Researchers analysed more than 100 stool samples from the man and found mutated versions of the polio virus capable of causing paralysis. They believe he has been shedding the mutated strain for 28 years.
The man had a full course of polio vaccinations, which included three doses of weakened live virus at 5, 7 and 12 months, followed by a booster jab when he was about seven years old. He was later diagnosed with a condition that suppresses the immune system, affecting its ability to kill viruses in his gut.
Tests on the viruses found in the man’s stool samples revealed they had mutated from the weakened form used in the vaccines into a more dangerous strain.
People who are fully vaccinated against polio are not at risk, but in countries where routine vaccination is not encouraged, similar immune-deficient patients could potentially start a new polio outbreak.
The man received the older oral polio vaccine (OPV) that contained a weakened form of the virus, and was often given on a sugar cube. In 2004, the UK switched to an inactivated polio vaccine (IPV) which is injected.
The discovery, reported in the journal Plos Pathogens, has implications for health officials who are close to eradicating polio from the three remaining countries where the virus is still circulating: Pakistan, Afghanistan and Nigeria.
Before the disease can be completely wiped out, mutated strains of polio virus derived from vaccines must be tackled. To that end, the World Health Organisation is set to trial a new vaccine next April.
But work still needs to be done to eradicate polio worldwide, and this discovery of a mutated poliovirus in the UK, among others in Slovakia, Finland and Estonia, presents an extra hurdle before the finish line.
“These viruses could potentially cause poliomyelitis in susceptible people, so it is very important to maintain high levels of vaccine coverage,” said Javier Martin of the UK National Institute for Biological Standards and Control.
“We are working on an end-game strategy,” he added.
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