Leonard Nimoy, well known as Star Treks Mr. Spock, died on Friday morning at his home in the Bel Air section of Los Angeles at the age of 83.
His wife confirmed his death, saying the cause was end-stage chronic obstructive pulmonary disease.
Mr. Nimoy who was hospitalised earlier this week announced that he had the disease last year and had attributed it to many years of smoking, a habit he had given up three decades earlier.
The BBC report: Nimoy had a long career as both an actor and director.
However he was best known for his portrayal of the half-human, half-Vulcan character in both the TV franchise and series of films.
Last year, the actor revealed he was suffering from chronic lung disease, despite stopping smoking more than 20 years ago.
It was reported earlier this week he had been taken to hospital on 19 February after suffering from chest pains.
He later tweeted: “A life is like a garden. Perfect moments can be had, but not preserved, except in memory.”
He signed off with “LLAP” – a reference to his character’s famous catchphrase, “Live long and prosper”. It was to be his final tweet.